Description

Zolmitriptan n-Oxide CAS NO 251451-30-6 is a key pharmaceutical intermediate and metabolite of the active drug substance Zolmitriptan. This compound is of significant importance in the research, development, and quality control of triptan-class migraine therapeutics. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, impurity profiling, and reference standard synthesis.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the identification and quantification of the N-oxide metabolite in drug substance and product analysis.
• Impurity Profiling: Critical for monitoring and controlling the N-oxide impurity during the manufacturing and stability testing of Zolmitriptan Active Pharmaceutical Ingredient (API).
• Metabolite Research: Used in preclinical and clinical studies to understand the pharmacokinetics, metabolism, and excretion pathways of Zolmitriptan.
• Analytical Method Development: Essential for developing and validating robust HPLC, UPLC, or LC-MS/MS methods for related substance testing.
• Process Chemistry: Employed as an intermediate or marker in the synthesis and process optimization of Zolmitriptan and its derivatives.
• Regulatory Compliance: Supports regulatory filings (e.g., FDA, EMA) by providing characterized impurity standards for New Drug Applications (NDAs) and Marketing Authorisation Applications (MAAs).

Basic Information

Product Name	Zolmitriptan n-Oxide
CAS No.	251451-30-6
Molecular Formula	C16H21N3O3
Molecular Weight	303.36 g/mol
Synonyms	(S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone N-Oxide; Zolmitriptan Impurity F (N-Oxide); Zolmitriptan N-Oxide Metabolite; Zolmitriptan Related Compound F; 251451-30-6; Zolmitriptan Oxide
EINECS	Contact for details

Quality Control

Our Zolmitriptan n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical reference standards and advanced intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥95% by HPLC), and impurity profile. We support compliance with ICH guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Maximum Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.