Description

2-(Dicyclohexylphosphino)-2'-Methylbiphenyl is a specialized, high-value organophosphorus ligand widely used in transition metal catalysis. This compound matters for its exceptional ability to facilitate challenging cross-coupling reactions, enabling the efficient synthesis of complex molecules. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate Synthesis: A key ligand for Buchwald-Hartwig amination, Suzuki-Miyaura, and other C-N/C-C cross-coupling reactions critical for constructing active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in catalytic processes to create novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science R&D: Facilitates the synthesis of organic electronic materials, such as OLED and OFET components, through precise coupling reactions.
• Academic & Industrial Catalysis Research: Serves as a privileged ligand in developing new catalytic methodologies and optimizing reaction conditions for scale-up.
• Fine Chemical Production: Enables the efficient and selective synthesis of complex, high-value specialty chemicals used as flavors, fragrances, and dyes.

Basic Information

Product Name	2-(Dicyclohexylphosphino)-2'-Methylbiphenyl
CAS No.	251320-86-2
Molecular Formula	C25H33P
Molecular Weight	364.51 g/mol
Synonyms	2-(Dicyclohexylphosphino)-2'-methyl-1,1'-biphenyl; DavePhos; Methylbiphenyl DavePhos; 2-Methyl-2'-(dicyclohexylphosphino)biphenyl; 2'-Methyl-2-(dicyclohexylphosphino)biphenyl; 2-(Dicyclohexylphosphanyl)-2'-methylbiphenyl; 2-(Dicyclohexylphosphino)-2'-methylbiphenyl ligand
EINECS	Contact for details

Quality Control

Our production of 2-(Dicyclohexylphosphino)-2'-Methylbiphenyl adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by NMR (1H, 13C, 31P), HPLC, and elemental analysis to verify identity, purity, and the absence of critical impurities like phosphine oxides. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). This compound is easily oxidized; minimize exposure to air during handling and use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR Purity	≥ 98.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.