Description

2-(Dicyclohexylphosphino)-2'-Isopropylbiphenyl is a specialized, high-value phosphine ligand widely used in transition metal catalysis. This compound is critical for enabling highly efficient and selective cross-coupling reactions, which are fundamental to modern pharmaceutical and fine chemical synthesis. It is an essential tool for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials industries seeking to optimize catalytic processes for scale-up.

Application

• Catalyst Ligand for Cross-Coupling Reactions: A key component in Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings for C-N and C-C bond formation.
• Pharmaceutical Intermediate Synthesis: Used in the development and manufacturing of active pharmaceutical ingredients (APIs), enabling more efficient and cleaner synthetic routes.
• Agrochemical Production: Facilitates the synthesis of complex molecules for herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the catalysis for creating novel polymers and organic electronic materials.
• Process Chemistry Optimization: Valued for its ability to allow reactions to proceed under milder conditions with higher yields, improving manufacturing efficiency.
• Academic and Industrial R&D: A staple reagent in laboratories for methodological development and exploring new catalytic transformations.

Basic Information

Product Name	2-(Dicyclohexylphosphino)-2'-Isopropylbiphenyl
CAS No.	251320-85-1
Molecular Formula	C27H37P
Molecular Weight	392.56 g/mol
Synonyms	2-(Dicyclohexylphosphino)-2'-(1-methylethyl)-1,1'-biphenyl; 2'-Isopropyl-2-(dicyclohexylphosphino)biphenyl; DavePhos; RuPhos Ligand Precursor; CPhos; Biarylphosphine Ligand; 2-Dicyclohexylphosphino-2'-isopropylbiphenyl
EINECS	Contact for details

Quality Control

Every batch of 2-(Dicyclohexylphosphino)-2'-Isopropylbiphenyl is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the ligand meets the high-purity standards required for sensitive catalytic applications. A detailed Certificate of Analysis (COA) including assay (HPLC/NMR), identity confirmation, and impurity profile is supplied with each shipment to guarantee batch-to-batch consistency and performance reliability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and stored in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.