Description

tert-Butyl ((4-Cyanothiazol-2-Yl)Methyl)Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a cyano-substituted thiazole ring protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile handle for further functionalization in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the areas of kinase inhibitors and other small-molecule drugs.

Application

• Key building block in the research and development of pharmaceutical active ingredients (APIs), especially kinase inhibitors.
• Advanced intermediate for the synthesis of proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules.
• Precursor in medicinal chemistry for constructing thiazole-based heterocyclic scaffolds with potential biological activity.
• Used in process chemistry and scale-up studies for new drug candidates.
• Valuable reagent in academic and industrial R&D for exploring new chemical entities.

Basic Information

Product Name	tert-Butyl ((4-Cyanothiazol-2-Yl)Methyl)Carbamate
CAS No.	251294-64-1
Molecular Formula	C10H13N3O2S
Molecular Weight	239.29 g/mol
Synonyms	Boc-4-Cyanothiazol-2-ylmethylamine; 2-(((tert-Butoxycarbonyl)amino)methyl)thiazole-4-carbonitrile; tert-Butyl N-[(4-cyanothiazol-2-yl)methyl]carbamate; Carbamic acid, N-[(4-cyano-2-thiazolyl)methyl]-, 1,1-dimethylethyl ester; 2-Thiazolecarbonitrile, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-; (4-Cyano-thiazol-2-ylmethyl)-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl ((4-Cyanothiazol-2-Yl)Methyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support development and commercial projects with material suitable for research use and can provide grades aligned with current Good Manufacturing Practice (cGMP) standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.