Description

Telmisartan Acyl-β-D-Glucuronide is a major, pharmacologically relevant Phase II metabolite of the angiotensin II receptor blocker (ARB) telmisartan. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK) and bioanalytical method development. It serves as a vital reference standard for scientists in pharmaceutical companies, contract research organizations (CROs), and academic institutions requiring high-purity materials for analytical and metabolic studies.

Application

• Pharmaceutical Reference Standard: Primary use as a certified standard for the quantification and identification of telmisartan metabolites in biological matrices (plasma, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to understand the metabolic pathways, clearance mechanisms, and exposure levels of telmisartan.
• Bioanalytical Method Development & Validation: Used to develop, calibrate, and validate sensitive LC-MS/MS or HPLC methods for clinical and preclinical studies.
• Impurity Profiling and Characterization: Acts as a known impurity or degradation product reference in the quality control of telmisartan active pharmaceutical ingredient (API) and finished dosage forms.
• Toxicology and Safety Assessment: Employed in studies to assess the safety profile and potential biological activity of telmisartan metabolites.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) to support the safety and efficacy profile of telmisartan-based drugs.

Basic Information

Product Name	Telmisartan Acyl-β-D-Glucuronide
CAS No.	250780-40-6
Molecular Formula	C39H38N4O9
Molecular Weight	706.75 g/mol
Synonyms	Telmisartan Acyl Glucuronide; Telmisartan 1-O-β-Acyl Glucuronide; Telmisartan Glucuronide Metabolite; BIBS 277 glucuronide; 4'-[(1,7'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid β-D-Glucopyranosiduronic acid ester; (2'-(1H-Tetrazol-5-yl)[1,1'-biphenyl]-4-yl)methyl 2-butyl-4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)benzimidazole-1-carboxylate β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Telmisartan Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support compliance needs for research under GLP (Good Laboratory Practice) conditions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.