Description

n-tert-Butyl-n-Fmoc-Glycine CAS NO 250695-67-1 is a specialized N-protected amino acid derivative, serving as a crucial building block in modern organic synthesis. Its value lies in the dual protection strategy, where the tert-butyl group offers acid-labile protection and the Fmoc group provides base-labile protection, enabling sophisticated, orthogonal peptide synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential assembly of complex peptide chains.
• Solution-Phase Peptide Synthesis: Used in the preparation of peptide fragments and small peptides in solution.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and production of therapeutic peptides and related drug candidates.
• Bioconjugation: Facilitates the site-specific modification of proteins, antibodies, or other biomolecules by introducing a glycine spacer with orthogonal protecting groups.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic chemistry and peptide science.

Basic Information

Product Name	n-tert-Butyl-n-Fmoc-Glycine
CAS No.	250695-67-1
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine; N-Boc-N-Fmoc-glycine; (tert-Butoxycarbonyl)(9-fluorenylmethoxycarbonyl)aminoacetic Acid; Boc-Fmoc-Gly-OH; N-(tert-Butoxycarbonyl)-N-(9-fluorenylmethoxycarbonyl)glycine; 2-[(tert-Butoxycarbonyl)(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic Acid; Nα-Boc-Nα-Fmoc-glycine
EINECS	Contact for details

Quality Control

Our n-tert-Butyl-n-Fmoc-Glycine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.