Description

Cyclic Arg-Gly-Asp-D-Tyr-Lys is a synthetic, cyclic pentapeptide featuring the Arg-Gly-Asp (RGD) motif, a critical sequence for cell adhesion and signaling. This compound is engineered for high-affinity binding to integrin receptors, making it a powerful tool for modulating cellular interactions. It is essential for researchers and developers in pharmaceutical R&D, diagnostic assay development, and biomaterials science who require precise control over cell behavior.

Application

• Integrin Research & Drug Discovery: Used as a high-affinity ligand or competitive inhibitor in studies targeting αvβ3, αvβ5, and other RGD-sensitive integrins for oncology and anti-angiogenesis applications.
• Biomaterial & Tissue Engineering: Functionalizes surfaces of scaffolds, implants, and hydrogels to promote specific cell attachment, spreading, and tissue integration.
• Diagnostic Development: Serves as a capture or detection agent in ELISA, flow cytometry, and other assays designed to study integrin expression or function.
• Cell Culture & Signaling Studies: Applied in vitro to investigate cell adhesion, migration, proliferation, and survival pathways mediated by integrin receptors.
• Targeted Drug Delivery Systems: Conjugated to nanoparticles or liposomes to create targeted delivery vehicles for chemotherapeutic agents to tumor sites.
• Antithrombotic Research: Investigated for its potential to inhibit platelet aggregation by interfering with fibrinogen binding to integrin αIIbβ3.

Basic Information

Product Name	Cyclic Arg-Gly-Asp-D-Tyr-Lys
CAS No.	250612-42-1
Molecular Formula	C30H46N12O8
Molecular Weight	678.8 g/mol
Synonyms	c(RGDyK); Cyclo(Arg-Gly-Asp-D-Tyr-Lys); cRGDyK peptide; Cyclic RGDyK; Cyclo(RGDyK); Cyclo(-Arg-Gly-Asp-D-Tyr-Lys-); c[RGDyK]; RGD Cyclic Pentapeptide
EINECS	Contact for details

Quality Control

Our Cyclic Arg-Gly-Asp-D-Tyr-Lys is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide Certificates of Analysis (COA) with detailed specifications for purity (typically ≥95% by HPLC), peptide content, and solvent residues, ensuring consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider lyophilized powder under inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.