Description

(Z)-8-Hydroxy Doxepin CAS NO 250331-51-2 is a specific stereoisomer and hydroxylated derivative of the tricyclic antidepressant doxepin, serving as a crucial pharmaceutical intermediate and reference standard. This compound is of significant value for research and development in neuropharmacology, enabling the study of metabolic pathways and the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) and high-purity fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced doxepin analogs and related tricyclic compounds for pharmacological research.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for the identification and quantification of 8-hydroxydoxepin metabolites in biological matrices during drug metabolism and pharmacokinetic (DMPK) studies.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate the structure-activity relationships (SAR) and metabolic profiles of tricyclic antidepressants.
• Analytical Method Development: Serves as a high-purity standard for calibrating equipment and validating methods in HPLC, LC-MS, and other chromatographic techniques.
• Quality Control (QC) Testing: Essential for the quality assurance and release testing of doxepin-based active pharmaceutical ingredients (APIs) and finished dosage forms.

Basic Information

Product Name	(Z)-8-Hydroxy Doxepin
CAS No.	250331-51-2
Molecular Formula	C19H21NO2
Molecular Weight	295.38 g/mol
Synonyms	(Z)-8-Hydroxydoxepin; (Z)-1-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-ol; 8-Hydroxy Doxepin (Z-isomer); (Z)-Doxepin 8-ol; 8-OH-Doxepin (cis); cis-8-Hydroxydoxepin; NSC 339024; Doxepin metabolite M1 (Z-form)
EINECS	Contact for details

Quality Control

Our (Z)-8-Hydroxy Doxepin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and reference standard applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.