Description

3-tert-Butoxycarbonylamino-4-Methyl-Pentanoic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the controlled introduction of a sterically hindered, branched amino acid moiety into complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and biotechnology sectors for the synthesis of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, including protease inhibitors and other bioactive peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a protected leucine-like amino acid residue with a tert-butoxycarbonyl (Boc) protecting group on the amine.
• Prodrug Development: Employed in the design and synthesis of prodrugs where the carboxylic acid functionality can be modified to enhance bioavailability or targeting.
• Chemical Biology Research: Serves as a building block for creating custom amino acids and molecular probes to study protein-protein interactions and enzyme mechanisms.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, chiral agrochemicals requiring specific stereochemistry for optimal activity.
• Material Science: Can be utilized in the synthesis of specialized polymers and dendrimers with amino acid-based backbones for biomedical applications.

Basic Information

Product Name	3-tert-Butoxycarbonylamino-4-Methyl-Pentanoic Acid
CAS No.	248924-39-2
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	Boc-4-methyl-DL-norvaline; 3-[(tert-Butoxycarbonyl)amino]-4-methylpentanoic acid; 4-Methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid; (RS)-3-(Boc-amino)-4-methylpentanoic acid; DL-3-(tert-Butoxycarbonylamino)-4-methylvaleric acid; Boc-Amino(4-methyl)valeric acid; N-Boc-4-methylnorvaline; Boc-4-Me-Nva-OH
EINECS	Contact for details

Quality Control

Our 3-tert-Butoxycarbonylamino-4-Methyl-Pentanoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR/IR for structural confirmation, to ensure it meets the exacting standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.