Description

L-Methionine, n-[(1,1-Dimethylethoxy)Carbonyl]-L-Histidyl- (9Ci) is a protected dipeptide derivative, specifically a Boc-protected methionine-histidine building block. This compound is of critical importance for the controlled synthesis of peptides and peptidomimetics, offering precise control over amino acid sequence and protecting group strategy. It is primarily required by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key, high-purity building block for the sequential assembly of custom peptides.
• Medicinal Chemistry & Drug Discovery: For the research and development of peptide-based pharmaceuticals, including hormone analogs and enzyme inhibitors.
• Bioconjugation & Labeling: Serving as a specialized intermediate for attaching peptides to other molecules, such as dyes, polymers, or drug delivery systems.
• Biochemical Research: Used in studies of protein-protein interactions, enzyme substrates, and receptor ligands where specific peptide sequences are required.
• Process Development: For scaling up the production of target peptide sequences in a Good Manufacturing Practice (GMP) or pilot-plant environment.

Basic Information

Product Name	L-Methionine, n-[(1,1-Dimethylethoxy)Carbonyl]-L-Histidyl- (9Ci)
CAS No.	248921-84-8
Molecular Formula	C17H27N5O5S
Molecular Weight	413.49 g/mol
Synonyms	Boc-Met-His-OH; Boc-L-Methionyl-L-histidine; tert-Butoxycarbonylmethionylhistidine; Nα-Boc-Methionine-Histidine; N-[(1,1-Dimethylethoxy)carbonyl]-L-methionyl-L-histidine; Boc-Met-His; (S)-2-((S)-2-((tert-Butoxycarbonyl)amino)-4-(methylthio)butanamido)-3-(1H-imidazol-4-yl)propanoic acid; L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-L-methionyl-
EINECS	Contact for details

Quality Control

Our L-Methionine, n-[(1,1-Dimethylethoxy)Carbonyl]-L-Histidyl- (9Ci) is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring compliance with research and development standards. Custom synthesis to meet specific purity requirements (e.g., >98%, >99%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.