Description

Diethyl 2,5-Difluorophenylmalonate is a high-purity fluorinated organic building block, specifically a substituted malonate ester. This compound is valued for its role as a versatile synthetic intermediate in advanced organic synthesis, enabling the introduction of a difluorophenyl moiety. It is primarily required by R&D and production chemists in the pharmaceutical and agrochemical industries for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display and lighting technologies.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into specialty polymers, improving their chemical resistance and thermal properties.
• Chemical Research & Development: A crucial reagent for method development and exploring new fluorination strategies in academic and industrial laboratories.
• Fine Chemical Production: Used in the multi-step synthesis of complex fluorinated fine chemicals and dyes.

Basic Information

Product Name	Diethyl 2,5-Difluorophenylmalonate
CAS No.	247170-23-6
Molecular Formula	C₁₃H₁₄F₂O₄
Molecular Weight	272.25 g/mol
Synonyms	Diethyl (2,5-difluorophenyl)malonate; 2,5-Difluorophenylmalonic Acid Diethyl Ester; Propanedioic acid, (2,5-difluorophenyl)-, diethyl ester; Diethyl 2-(2,5-difluorophenyl)malonate; (2,5-Difluorophenyl)malonic acid diethyl ester; Diethyl (2,5-difluorobenzyl)malonate (common misnomer); 247170-23-6; DFPM
EINECS	Contact for details

Quality Control

Our Diethyl 2,5-Difluorophenylmalonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.