Description

n-α –Fmoc-n-β-1-(4,4-Dimethyl-2,6-Dioxocyclohe CAS NO 247127-51-1 is a specialized, high-purity Fmoc-protected amino acid derivative used as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise and efficient construction of complex peptides and peptidomimetics, which are essential for pharmaceutical research and development. This compound is particularly vital for medicinal chemists and process development scientists working in drug discovery, especially for the synthesis of novel therapeutic candidates targeting various diseases.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of peptides on resin, particularly for introducing specific, non-natural amino acid motifs.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of new active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Development: Used to create peptide-like molecules with enhanced stability, bioavailability, and pharmacological properties for therapeutic applications.
• Bioconjugation and Probe Synthesis: Facilitates the site-specific labeling and modification of peptides for diagnostic, imaging, and biochemical research tools.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Academic and Industrial R&D: Supports fundamental research in organic chemistry, biochemistry, and medicinal chemistry within universities, CROs, and biotech/pharma companies.

Basic Information

Product Name	n-α –Fmoc-n-β-1-(4,4-Dimethyl-2,6-Dioxocyclohe CAS NO 247127-51-1
CAS No.	247127-51-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Fmoc-β-homoGlu(ODmab)-OH; N-α-Fmoc-N-β-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)-L-glutamic acid; Fmoc-Glu(ODmab)-OH derivative; Fmoc-protected glutamic acid side-chain derivative; (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-{[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]amino}-5-oxopentanoic acid; Protected Fmoc-Glutamic Acid; Peptide synthesis building block 247127-51-1
EINECS	Contact for details

Quality Control

Our n-α –Fmoc-n-β-1-(4,4-Dimethyl-2,6-Dioxocyclohe CAS NO 247127-51-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.