Description

Fmoc-L-4-Trifluoromethylphe CAS NO 247113-86-6 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to introduce the unique 4-(trifluoromethyl)-L-phenylalanine residue, a non-natural amino acid that imparts enhanced metabolic stability, lipophilicity, and conformational rigidity to therapeutic peptides. It is a critical building block for pharmaceutical R&D teams and fine chemical manufacturers developing novel peptide-based drugs, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a key Fmoc-protected building block for the automated synthesis of custom peptides.
• Pharmaceutical Research: Incorporation into peptide drug candidates to improve bioavailability, binding affinity, and resistance to enzymatic degradation.
• Chemical Biology & Proteomics: Synthesis of peptide probes and activity-based probes (ABPs) containing a fluorinated aromatic side chain for 19F NMR studies or as a spectroscopic label.
• Agrochemical Development: Used in the research of novel bioactive peptides for crop protection.
• Material Science: A precursor for synthesizing specialized peptides used in biomaterials and surface functionalization.

Basic Information

Product Name	Fmoc-L-4-Trifluoromethylphe
CAS No.	247113-86-6
Molecular Formula	C25H20F3NO4
Molecular Weight	455.43 g/mol
Synonyms	Fmoc-4-CF3-Phe-OH; Fmoc-L-4-(Trifluoromethyl)phenylalanine; N-(9-Fluorenylmethoxycarbonyl)-4-(trifluoromethyl)-L-phenylalanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(trifluoromethyl)phenyl]propanoic acid; Fmoc-TfmPhe-OH; Fmoc-4-Trifluoromethyl-L-phenylalanine; Nα-Fmoc-4-trifluoromethyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-4-Trifluoromethylphe is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for pharmaceutical research. Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccant and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.