Description

(20S)-Dexamethasone Epimeric Glycolic Acid CAS NO 247075-09-8 is a high-purity, advanced pharmaceutical intermediate derived from the corticosteroid dexamethasone. This compound is of significant value for the research and development of novel anti-inflammatory and immunosuppressive agents, serving as a critical building block for structural modifications. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on steroid-based drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of novel dexamethasone analogs and prodrugs.
• Drug Discovery Research: Used in medicinal chemistry programs to study structure-activity relationships (SAR) and develop new corticosteroid derivatives with improved efficacy or reduced side effects.
• Process Development: Serves as a reference standard or a critical intermediate in scaling up synthetic routes for steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized as a tool compound in studies investigating glucocorticoid receptor (GR) signaling pathways and metabolism.
• Analytical Standard: Employed as a high-purity reference standard for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical analysis.

Basic Information

Product Name	(20S)-Dexamethasone Epimeric Glycolic Acid
CAS No.	247075-09-8
Molecular Formula	C24H31FO7
Molecular Weight	450.50 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Glycolic Acid; Dexamethasone 21-Glycolic Acid Epimer; (20S)-Dexamethasone 21-Carboxymethyl Ether; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-Glycolic Acid (20S Epimer); Dexamethasone Glycolic Acid Derivative; Dexamethasone Carboxymethoxy Derivative
EINECS	Contact for details

Quality Control

Our (20S)-Dexamethasone Epimeric Glycolic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.