Description

(S)-tert-Butyl 2-(2-(((Benzyloxy)Carbonyl)Amino)-5-((tert-Butoxycarbonyl)Amino)-n-(2,2-Dimethoxyethyl)Pentanamido)Acetate CAS NO 247068-70-8 is a sophisticated, multi-protected amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is critical for constructing complex peptide sequences with high stereochemical fidelity, enabling the development of novel therapeutic agents and biochemical tools. It is primarily utilized by pharmaceutical R&D teams, CROs/CDMOs, and academic researchers focused on peptide-based drug discovery and proteomics.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block for the controlled incorporation of specific amino acid residues, particularly where orthogonal protecting group strategies are required.
• Solution-Phase Peptide Coupling: Used in the synthesis of complex peptide fragments and small proteins in solution, offering flexibility in synthetic routes.
• Medicinal Chemistry & Drug Discovery: A vital intermediate for creating peptide mimetics, constrained peptides, and other bioactive molecules targeting various disease pathways.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling and modification of peptides for diagnostic, imaging, and biochemical assay applications.
• Process Development & Scale-Up: Supports the optimization and manufacturing of peptide active pharmaceutical ingredients (APIs) under cGMP conditions.
• Academic Research: Enables studies in peptide structure-activity relationships (SAR), enzyme substrates, and receptor ligands.

Basic Information

Product Name	(S)-tert-Butyl 2-(2-(((Benzyloxy)Carbonyl)Amino)-5-((tert-Butoxycarbonyl)Amino)-n-(2,2-Dimethoxyethyl)Pentanamido)Acetate
CAS No.	247068-70-8
Molecular Formula	C28H45N3O9
Molecular Weight	567.68 g/mol
Synonyms	Boc-Lys(Z)-Ace-OtBu; Nα-Cbz-Nε-Boc-L-Lysine Acetic Acid tert-Butyl Ester; (S)-tert-Butyl 2-((2-((((Benzyloxy)carbonyl)amino)-5-((tert-butoxycarbonyl)amino)pentanamido)acetate; Nα-Z-Nε-Boc-L-Lys-Ace-OtBu; Fmoc-Lys(Boc)-OH related building block; Protected Lysine Derivative; Peptide Synthesis Intermediate 247068-70-8; Ac-Lys(Z,Boc)-OtBu analog
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 2-(2-(((Benzyloxy)Carbonyl)Amino)-5-((tert-Butoxycarbonyl)Amino)-n-(2,2-Dimethoxyethyl)Pentanamido)Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.