Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Hydroxyphenyl)-2-Methylpropanoic Acid is a high-purity, non-natural amino acid derivative featuring a protected amine (Fmoc) group and a phenolic side chain. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the precise introduction of structural and functional diversity. It is essential for research and development in pharmaceutical discovery, particularly for creating novel therapeutic agents targeting metabolic and neurological disorders. The CAS number for this compound is 246539-83-3.

Application

• Pharmaceutical Research & Development: A key chiral intermediate for the synthesis of novel peptide-based drug candidates and bioactive molecules.
• Solid-Phase Peptide Synthesis (SPPS): Used as an Fmoc-protected amino acid building block for the automated synthesis of custom peptides with specific sequences and modifications.
• Peptidomimetic Design: Incorporates a unique methylated backbone and phenolic functionality to enhance metabolic stability, bioavailability, and receptor binding affinity in designed compounds.
• Chemical Biology Probes: Serves as a precursor for labeled or tagged amino acids used to study protein-protein interactions and enzyme mechanisms.
• Academic & Institutional Research: Utilized in laboratories for investigating protein folding, structure-activity relationships (SAR), and new synthetic methodologies.
• Contract Manufacturing (CMO/CDMO): Supplied as a high-quality raw material for the cGMP production of Active Pharmaceutical Ingredients (APIs) in clinical and commercial batches.

Basic Information

Item	Details
Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Hydroxyphenyl)-2-Methylpropanoic Acid
CAS No.	246539-83-3
Molecular Formula	C26H23NO5
Molecular Weight	429.46 g/mol
Synonyms	Fmoc-4-hydroxy-D-phenylalanine(2-Me); Fmoc-D-Tyr(2-Me)-OH; Fmoc-2-Methyl-D-tyrosine; (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-hydroxyphenyl)-2-methylpropanoic acid; (S)-2-(Fmoc-amino)-3-(4-hydroxyphenyl)-2-methylpropionic acid; Fmoc-D-Tyr(Me)-OH; Fmoc-2-Me-D-Tyr-OH; Fmoc-(2-Me)D-Tyr-OH
EINECS	Contact for details

Quality Control

Our (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Hydroxyphenyl)-2-Methylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We can support development with custom purity grades and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.