Description

(S)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Naphthalen-2-Yl-Acetic Acid CAS NO 246509-57-9 is a high-purity, non-natural amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel therapeutic agents and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the automated synthesis of custom peptides with specific naphthylalanine substitutions.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for drugs targeting protein-protein interactions or requiring enhanced aromatic character.
• Peptidomimetic Design: Essential for creating peptide analogs where the naphthalene ring system is used to mimic natural side chains, improve metabolic stability, or modulate lipophilicity.
• Bioconjugation & Probe Development: Acts as a precursor for fluorescent or affinity probes used in biochemical assays and diagnostic research due to its aromatic naphthyl moiety.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental studies in medicinal chemistry, chemical biology, and asymmetric synthesis.

Basic Information

Item	Detail
Product Name	(S)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Naphthalen-2-Yl-Acetic Acid
CAS No.	246509-57-9
Molecular Formula	C31H25NO4
Molecular Weight	475.54 g/mol
Synonyms	Fmoc-2-Nal-OH; Fmoc-2-Naphthylalanine; Fmoc-L-2-Nal-OH; (S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(naphthalen-2-yl)propanoic acid; N-α-Fmoc-L-2-naphthylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-2-naphthylalanine; Fmoc-Naphthalen-2-yl-L-alanine; L-Fmoc-2-Naphthylalanine
EINECS	Contact for details

Quality Control

Our production of (S)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Naphthalen-2-Yl-Acetic Acid adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical research and peptide synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.