Description

(R)-(+)-2-[2-(Diphenylphosphino)Phenyl]-1,2,3-Dinaphtho(D12,F12)Dioxaphosphine is a high-value, chiral phosphine ligand designed for asymmetric catalysis. This compound is critical for enabling highly enantioselective transformations in the synthesis of complex organic molecules. It is primarily needed by research institutions and pharmaceutical companies developing advanced active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component in enantioselective C-C and C-X bond-forming reactions.
• Key reagent in the synthesis of optically pure compounds for agrochemical and material science research.
• Used in academic and industrial R&D for developing novel catalytic processes.
• Facilitates the production of single-enantiomer drugs to meet stringent regulatory requirements.
• Employed in the fine-tuning of catalyst systems for improved yield and selectivity.

Basic Information

Product Name	(R)-(+)-2-[2-(Diphenylphosphino)Phenyl]-1,2,3-Dinaphtho(D12,F12)Dioxaphosphine
CAS No.	245430-28-8
Molecular Formula	C44H30O2P2
Molecular Weight	652.66 g/mol
Synonyms	(R)-DTBM-D12-F12-SEGPHOS; (R)-(+)-2-[2-(Diphenylphosphino)phenyl]-4,4',5,5',6,6',7,7',8,8',9,9'-dodecahydro-1,2,3-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine; (R)-DTBM-SEGPHOS(D12,F12); (R)-3,3',5,5'-Tetra-tert-butyl-4,4',6,6'-tetramethyl-2,2'-biphenyldiyl-bis(dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine) (D12,F12); (R)-DTBM-SEGPHOS with D12 and F12 labels; SEGPHOS derivative, deuterated and fluorinated.
EINECS	Contact for details

Quality Control

Our (R)-(+)-2-[2-(Diphenylphosphino)Phenyl]-1,2,3-Dinaphtho(D12,F12)Dioxaphosphine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/NMR), and chiral purity. We adhere to cGMP standards where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.