Description

Propanoyl Chloride, 3,3,3-Trifluoro-2-Hydroxy-2-Methyl- is a specialized fluorinated acid chloride derivative that serves as a critical building block in advanced organic synthesis. Its unique trifluoromethyl and hydroxyl functionalities make it a valuable reagent for introducing fluorinated motifs, which are essential for modulating the physicochemical properties of target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated drug candidates, particularly in protease inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of fluorinated monomers for specialty polymers with enhanced chemical resistance and surface properties.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated components in electronic display and lighting materials.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed and other metal-mediated coupling reactions to construct complex fluorinated architectures.
• Peptide & Protein Modification: Used for selective acylation reactions to incorporate fluorinated labels or alter peptide backbone properties.

Basic Information

Product Name	Propanoyl Chloride, 3,3,3-Trifluoro-2-Hydroxy-2-Methyl-
CAS No.	243869-56-9
Molecular Formula	C4H4ClF3O2
Molecular Weight	176.52 g/mol
Synonyms	2-Hydroxy-2-methyl-3,3,3-trifluoropropanoyl chloride; 3,3,3-Trifluoro-2-hydroxy-2-methylpropionyl chloride; α-Hydroxy-α-methyl-3,3,3-trifluoropropionyl chloride; 2-Methyl-3,3,3-trifluoro-2-hydroxypropanoyl chloride; TFHMP-Cl; TFMHP chloride
EINECS	Contact for details

Quality Control

Our Propanoyl Chloride, 3,3,3-Trifluoro-2-Hydroxy-2-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, assay, and impurity profiles are available for every lot. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Density (at 20°C)	~1.45 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.