Description

Benzene, 1-Fluoro-3-[(1R,2R)-2-Methylcyclopropyl]-, Rel- (9Ci) is a specialized fluorinated benzene derivative featuring a chiral, trans-configured methylcyclopropyl substituent. This compound is a high-value chiral building block critical for the synthesis of complex molecules in advanced research and development. It is primarily utilized by pharmaceutical and agrochemical R&D teams for creating novel active ingredients, particularly where the introduction of fluorine and specific stereochemistry is required to modulate biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents and pesticides, where the fluorine atom and cyclopropyl group can enhance herbicidal or insecticidal activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for constructing sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or functional additive for developing specialty polymers with unique optical or electronic properties.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.

Basic Information

Item	Detail
Product Name	Benzene, 1-Fluoro-3-[(1R,2R)-2-Methylcyclopropyl]-, Rel- (9Ci)
CAS No.	243665-07-8
Molecular Formula	C10H11F
Molecular Weight	150.19 g/mol
Synonyms	1-Fluoro-3-[(1R,2R)-2-methylcyclopropyl]benzene; rel-(1R,2R)-1-(3-Fluorophenyl)-2-methylcyclopropane; 3-[(1R,2R)-2-Methylcyclopropyl]fluorobenzene; (1R,2R)-2-Methyl-1-(3-fluorophenyl)cyclopropane; Fluorinated Chiral Cyclopropane Derivative; Benzene, fluoro-methylcyclopropyl- (rel-(1R,2R) isomer)
EINECS	Contact for details

Quality Control

Every batch of Benzene, 1-Fluoro-3-[(1R,2R)-2-Methylcyclopropyl]-, Rel- (9Ci) is produced and analyzed under strict quality management protocols. We ensure high chiral purity and chemical integrity through advanced analytical techniques, including chiral HPLC, GC-MS, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain product stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.