Description

Benzyl Chlorofluoroacetate is a specialized fluorinated building block and reagent of significant interest in advanced organic synthesis. Its value lies in its bifunctional structure, incorporating both a reactive chlorofluoroacetate ester group and a benzyl protecting group, enabling precise molecular construction. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, pesticides, and fungicides where the introduction of fluorine atoms is critical for activity.
• Fluorination Reagent: Serves as a source of the -CHFCO- unit in nucleophilic substitution and other fluorination reactions under controlled conditions.
• Peptide Mimetics & PROTACs: Employed in medicinal chemistry for constructing peptide isosteres and linker components in proteolysis-targeting chimeras (PROTACs).
• Material Science Research: A precursor for developing novel fluorinated polymers, coatings, and liquid crystals with unique properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and interactions.

Basic Information

Product Name	Benzyl Chlorofluoroacetate
CAS No.	243659-11-2
Molecular Formula	C9H8ClFO2
Molecular Weight	202.61 g/mol
Synonyms	Benzyl 2-chloro-2-fluoroacetate; 2-Chloro-2-fluoroacetic Acid Benzyl Ester; Chlorofluoroacetic Acid Benzyl Ester; Benzyl Chlorofluoroethanoate; (Benzyloxycarbonyl)chlorofluoromethane; α-Chloro-α-fluoroacetic Acid Benzyl Ester; Benzyl Ester of Chlorofluoroacetic Acid
EINECS	Contact for details

Quality Control

Our Benzyl Chlorofluoroacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications. We support development projects requiring material that meets internal quality standards or specific customer protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.