Description

(1R,2S)-2-[n-Benzyl-n-(Mesitylenesulfonyl)Amino]-1-Phenylpropyl Acetate CAS NO 240423-74-9 is a high-purity chiral intermediate featuring a complex sulfonamide-protected amine structure. This compound is critically valuable for its role in the stereoselective synthesis of advanced pharmaceutical agents, particularly in the development of enzyme inhibitors and receptor modulators. It is an essential building block for research and development chemists in the pharmaceutical and fine chemical industries who require high enantiomeric purity and reliable synthetic pathways for complex target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Catalysis Research: Used as a substrate or ligand precursor in the development and screening of novel asymmetric catalytic reactions.
• Medicinal Chemistry: Serves as a core scaffold for constructing compound libraries in drug discovery programs focused on structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs, ensuring reproducibility and cost-efficiency.
• Academic Research: Utilized in university and institutional labs for advanced studies in organic synthesis methodology and stereochemistry.
• Custom Synthesis: A starting point for contract research organizations (CROs) and CDMOs to manufacture bespoke compounds for client projects.

Basic Information

Product Name	(1R,2S)-2-[n-Benzyl-n-(Mesitylenesulfonyl)Amino]-1-Phenylpropyl Acetate
CAS No.	240423-74-9
Molecular Formula	C27H31NO4S
Molecular Weight	465.61 g/mol
Synonyms	(1R,2S)-2-[N-Benzyl-N-(2,4,6-trimethylbenzenesulfonyl)amino]-1-phenylpropyl acetate; (1R,2S)-2-[N-Benzyl-N-(mesitylsulfonyl)amino]-1-phenylpropyl acetate; N-Benzyl-N-mesitylsulfonyl-1-phenyl-2-propylamine acetate derivative; (1R,2S)-2-(Benzyl(mesitylsulfonyl)amino)-1-phenylpropyl acetate; Acetic acid (1R,2S)-2-[benzyl(mesitylsulfonyl)amino]-1-phenylpropyl ester; BMSA-PPA acetate; Mesitylenesulfonyl-protected chiral amine acetate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ state-of-the-art analytical techniques, including chiral HPLC, NMR, and mass spectrometry, to guarantee high chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your research or cGMP development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.