Description

Piperazinone, 6-(2-Methylpropyl)-, (6S)- (9Ci) is a chiral, non-natural amino acid derivative belonging to the piperazinone class of heterocyclic compounds. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and chiral ligands. It serves as a valuable building block for medicinal chemists and process development scientists in the pharmaceutical and fine chemical industries seeking to introduce specific stereochemistry and functional groups into complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including protease inhibitors, kinase inhibitors, and other small molecule drugs.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in asymmetric catalytic reactions to construct stereogenic centers with high enantiomeric purity.
• Peptidomimetics Development: Incorporated into peptide backbones to create peptidomimetic compounds with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study enzyme function and protein-protein interactions.
• Ligand Synthesis for Catalysis: Used in the preparation of chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Academic & Institutional Research: Employed in university and R&D institute laboratories for exploratory synthetic chemistry and methodology development.

Basic Information

Product Name	Piperazinone, 6-(2-Methylpropyl)-, (6S)- (9Ci)
CAS No.	239802-14-3
Molecular Formula	C8H16N2O
Molecular Weight	156.23 g/mol
Synonyms	(6S)-6-(2-Methylpropyl)piperazin-2-one; (S)-6-Isobutylpiperazin-2-one; L-Isobutylpiperazinone; (S)-6-(2-Methylpropyl)-2-piperazinone; 2-Piperazinone, 6-(2-methylpropyl)-, (6S)-; (S)-6-Isobutyl-2-piperazinone; (6S)-6-Isobutylpiperazin-2-one; (S)-6-(Isobutyl)piperazin-2-one
EINECS	Contact for details

Quality Control

Our Piperazinone, 6-(2-Methylpropyl)-, (6S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.