Description

5-Fluoro-2-(Trifluoromethyl)Phenylacetic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays (LCDs).
• Organic Electronics: Employed in the synthesis of novel organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Chemical Research: A versatile building block for Suzuki-Miyaura, Buchwald-Hartwig, and other cross-coupling reactions to create complex, fluorinated biaryl structures.
• Peptidomimetics & Prodrug Design: The phenylacetic acid moiety makes it suitable for incorporation into peptide analogs and prodrug linkers to improve drug delivery.

Basic Information

Product Name	5-Fluoro-2-(Trifluoromethyl)Phenylacetic Acid
CAS No.	239135-52-5
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	2-(5-Fluoro-2-(trifluoromethyl)phenyl)acetic acid; [5-Fluoro-2-(trifluoromethyl)phenyl]acetic acid; α-(5-Fluoro-2-(trifluoromethyl)phenyl)acetic acid; 5-Fluoro-2-trifluoromethylphenylacetic acid; 5-Fluoro-α-methyl-2-(trifluoromethyl)benzenacetic acid; 239135-52-5; 5-Fluoro-2-(trifluoromethyl)benzeneacetic acid
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Trifluoromethyl)Phenylacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources. Due to its acidic nature, handle with appropriate engineering controls and personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.