Description

Poly(Ethylene Glycol) Triphenylphosphine is a functionalized phosphine ligand where triphenylphosphine is covalently attached to a poly(ethylene glycol) (PEG) chain. This modification is crucial as it imparts amphiphilic properties, making the ligand soluble in both organic and aqueous phases, which is highly valuable for facilitating homogeneous catalysis and simplifying product isolation. This compound is primarily needed by researchers and process chemists in the pharmaceutical, fine chemical, and biotechnology industries for developing efficient and recyclable catalytic systems.

Application

• Homogeneous Catalysis: Acts as a versatile ligand for transition metal-catalyzed reactions, including cross-coupling (e.g., Suzuki, Heck), hydrogenation, and hydroformylation, often enabling catalyst recycling.
• Aqueous-Phase Synthesis: Facilitates organic reactions in water or biphasic systems due to its PEG-mediated solubility, promoting greener chemical processes.
• Polymer-Supported Reagents: Serves as a soluble polymer-supported reagent for Wittig reactions and other phosphorus-based transformations, combining the advantages of homogeneous reactivity with facile purification.
• Pharmaceutical Intermediate Synthesis: Used in the synthesis of complex drug molecules where phase-transfer catalysis or mild reaction conditions are required.
• Ligand for Nanoparticle Stabilization: Employed to stabilize metal nanoparticles in solution for catalytic applications, preventing aggregation.
• Material Science: Utilized in the surface functionalization of materials and the creation of smart, responsive polymers.

Basic Information

Product Name	Poly(Ethylene Glycol) Triphenylphosphine
CAS No.	238403-28-6
Molecular Formula	Typically CnH2n+1O(C2H4O)mP(C6H5)3 (Variable PEG chain length)
Molecular Weight	Variable, dependent on PEG chain length (n). Contact for details on specific grades.
Synonyms	PEG-Triphenylphosphine; PEGylated Triphenylphosphine; mPEG-TPP; Poly(ethylene glycol) monomethyl ether triphenylphosphine; Polyoxyethylene triphenylphosphine; Triphenylphosphine polyethylene glycol conjugate; Phosphine-PEG; Water-soluble triphenylphosphine ligand.
EINECS	Contact for details.

Quality Control

Our Poly(Ethylene Glycol) Triphenylphosphine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure consistent purity, functionality, and PEG chain length distribution. Key parameters monitored include phosphorous content, degree of functionalization, and residual solvents. Certificates of Analysis (COA) documenting these specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at room temperature (15-25°C). This compound is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided to maintain efficacy.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (P Content)	≥ 95% (or as per grade)
PEG Average Molecular Weight (Mn)	As specified (e.g., 350, 550, 750, 2000, 5000 Da)
Degree of Substitution	≥ 90%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.