Description

3,5-Bis(Trifluoromethyl)-Dl-Phenylalanine is a fluorinated derivative of the amino acid phenylalanine, characterized by the presence of two trifluoromethyl groups on the aromatic ring. This structural modification imparts unique physicochemical properties, making it a valuable non-natural amino acid building block for advanced chemical synthesis. It is primarily utilized by research institutions and industrial R&D departments engaged in the development of pharmaceuticals and agrochemicals. The compound serves as a critical intermediate for creating novel molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other therapeutic agents.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl groups can improve lipophilicity and biological activity.
• Peptidomimetics & Drug Design: Incorporated into peptide analogs to enhance stability against enzymatic degradation and to modulate receptor binding affinity.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals, leveraging the fluorine atoms to alter surface properties and dielectric constants.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological mechanisms and enzyme functions.
• Catalyst & Ligand Development: Acts as a chiral scaffold or precursor for synthesizing novel ligands used in asymmetric catalysis.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)-Dl-Phenylalanine
CAS No.	237076-69-6
Molecular Formula	C₁₁H₉F₆NO₂
Molecular Weight	301.19 g/mol
Synonyms	DL-3,5-Bis(trifluoromethyl)phenylalanine; 2-Amino-3-[3,5-bis(trifluoromethyl)phenyl]propanoic acid; (±)-3,5-Bis(trifluoromethyl)phenylalanine; 3,5-Bis(trifluoromethyl)-DL-α-phenylalanine; 3,5-Bis(trifluoromethyl)phenylalanine, DL-; 3,5-Bis(trifluoromethyl)-DL-phenylalanine; (RS)-3,5-Bis(trifluoromethyl)phenylalanine; α-Amino-3,5-bis(trifluoromethyl)benzenepropanoic acid
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)-Dl-Phenylalanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.