Description

1,4-Difluoro-2-(Methylsulfonyl)Benzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic combination of fluorine atoms and a methylsulfonyl group, which are critical for modulating the electronic properties, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro and sulfone motifs contribute to enhanced biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials requiring specific dielectric properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the activated fluorine atoms, enabling rapid diversification of chemical libraries.
• Fluorine Chemistry Research: A valuable reagent for studying nucleophilic aromatic substitution (SNAr) and other fluorine-specific reaction mechanisms in academic and industrial R&D settings.

Basic Information

Product Name	1,4-Difluoro-2-(Methylsulfonyl)Benzene
CAS No.	236739-03-0
Molecular Formula	C7H6F2O2S
Molecular Weight	192.18 g/mol
Synonyms	2,5-Difluorophenyl Methyl Sulfone; 1,4-Difluoro-2-(methanesulfonyl)benzene; 2-(Methylsulfonyl)-1,4-difluorobenzene; 2,5-Difluorobenzene-1-sulfonylmethane; Methyl 2,5-difluorophenyl sulfone; (2,5-Difluorophenyl)(methyl)sulfone; 236739-03-0; 1,4-Difluoro-2-methylsulfonylbenzene
EINECS	Contact for details

Quality Control

Our 1,4-Difluoro-2-(Methylsulfonyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.