Description

L-Serine, n-[(1R)-2-Methyl-1-[[(2,3,4,6-Tetra-o-Acetyl-β-D-Glucopyranosyl)Amino]Carbonyl]Propyl]-, Methyl Ester (9Ci) is a sophisticated, high-purity synthetic intermediate characterized by its complex molecular architecture, which combines a serine derivative with a protected glucopyranosyl moiety. This compound is of significant value in advanced pharmaceutical research and development, particularly in the synthesis of glycosylated peptides and enzyme inhibitors. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for creating novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex glycosylated peptides and glycopeptide mimetics for drug discovery programs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving glycosyltransferases or proteases, to investigate biological pathways.
• Medicinal Chemistry: Serves as a crucial precursor for the development of potential new chemical entities (NCEs) targeting metabolic disorders, infectious diseases, or cancer.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) requiring specific glycosylation patterns.
• Proteomics & Glycomics: Utilized in the design and synthesis of specialized probes and standards for mass spectrometry and other analytical techniques in systems biology.

Basic Information

Product Name	L-Serine, n-[(1R)-2-Methyl-1-[[(2,3,4,6-Tetra-o-Acetyl-β-D-Glucopyranosyl)Amino]Carbonyl]Propyl]-, Methyl Ester (9Ci)
CAS No.	236100-68-8
Molecular Formula	C24H36N2O12
Molecular Weight	544.55 g/mol
Synonyms	Methyl (2S)-2-[[(2R)-2-methyl-1-[[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)amino]carbonyl]propyl]amino]-3-hydroxypropanoate; L-Serine, N-[(1R)-2-methyl-1-[[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)amino]carbonyl]propyl]-, methyl ester; Ac4GlcNAc-Ser-OMe derivative; Glycosylated serine methyl ester intermediate; Protected glucosyl-serine conjugate; N-[(1R)-1-Carboxy-2-methylpropyl]-N'-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-L-serinamide methyl ester (isomeric form).
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under strict quality management systems to ensure exceptional purity and batch-to-batch consistency, critical for research and development applications. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity (typically by HPLC), identity confirmation (by NMR and/or IR), and specific impurity profiles. We support compliance with cGMP guidelines for investigational materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider holding under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.