Description

L-Glutamine, N2,N2-Bis(Phenylmethyl)-, Phenylmethyl Ester is a protected glutamine derivative, specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound is critical for researchers and manufacturers requiring precise control over glutamine's reactive side chain during complex coupling reactions. It serves as a key building block for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs) in the life sciences sector.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid derivative, it is essential for the controlled incorporation of glutamine into peptide chains without side reactions.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based therapeutics, including metabolic regulators and neurological agents.
• Bioconjugation Chemistry: Serves as a specialized reagent for creating peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions and enzyme mechanisms where glutamine plays a functional role.
• Process Development: Employed in scaling up the synthesis of complex peptides for preclinical and clinical studies.

Basic Information

Product Name	L-Glutamine, N2,N2-Bis(Phenylmethyl)-, Phenylmethyl Ester
CAS No.	235425-06-6
Molecular Formula	C26H28N2O3
Molecular Weight	416.52 g/mol
Synonyms	N2,N2-Dibenzyl-L-glutamine α-benzyl ester; L-Glutamine, N,N-dibenzyl-, benzyl ester; Fmoc-Gln(Bzl)-OBzl (common abbreviation); Benzyl N2,N2-dibenzyl-L-glutaminate; Glutamine derivative, dibenzyl protected; (S)-2-(Bis(benzyl)amino)-5-(benzyloxy)-5-oxopentanoic acid; Protected L-Glutamine benzyl ester; Peptide synthesis building block CAS 235425-06-6
EINECS	Contact for details

Quality Control

Our L-Glutamine, N2,N2-Bis(Phenylmethyl)-, Phenylmethyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency for critical research and development. We provide comprehensive analytical data, including HPLC purity, chiral purity (enantiomeric excess), and identity confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.