Description

5-Bromo-4,4,5,5-tetrafluoropentanoic acid is a high-value fluorinated organic building block characterized by its unique combination of a reactive bromine atom and a carboxylic acid group on a perfluorinated carbon chain. This compound matters as a versatile synthon for introducing fluorinated segments into target molecules, enabling the fine-tuning of lipophilicity, metabolic stability, and binding affinity in advanced chemical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the fluorinated moiety enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Incorporated as a monomer or cross-linking agent to create specialty fluoropolymers with enhanced chemical resistance and surface properties.
• Proteolysis-Targeting Chimera (PROTAC) Linkers: Utilized in the construction of bifunctional molecules for targeted protein degradation, leveraging its ability to modulate physicochemical properties.
• Positron Emission Tomography (PET) Tracer Precursor: Acts as a labeling synthon for introducing fluorine-18 or other radioisotopes for diagnostic imaging agents.

Basic Information

Product Name	5-Bromo-4,4,5,5-tetrafluoropentanoic Acid
CAS No.	234443-22-2
Molecular Formula	C5H5BrF4O2
Molecular Weight	237.00 g/mol
Synonyms	4,4,5,5-Tetrafluoro-5-bromopentanoic Acid; Pentanoic acid, 5-bromo-4,4,5,5-tetrafluoro-; 5-Bromo-4,4,5,5-tetrafluorovaleric Acid; 5-Bromoperfluoropentanoic Acid; 234443-22-2; Br(CF2)2CH2CH2COOH
EINECS	Contact for details

Quality Control

Our 5-Bromo-4,4,5,5-tetrafluoropentanoic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.