Description

4-Bromo-3,3,4,4-tetrafluorobutan-1-ol is a valuable fluorinated organic building block characterized by a bromine atom and a terminal hydroxyl group on a perfluorinated butane backbone. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms is desired to modulate properties like metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, where fluorine enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, improving properties such as chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: The bromine atom acts as a handle for versatile palladium-catalyzed reactions (e.g., Suzuki, Negishi) to create complex carbon-carbon bonds.
• Fluorinated Surfactant & Coating Precursor: Used to synthesize specialty surfactants and surface treatment agents with low surface energy.

Basic Information

Product Name	4-Bromo-3,3,4,4-tetrafluorobutan-1-ol
CAS No.	234443-21-1
Molecular Formula	C4H5BrF4O
Molecular Weight	225.0 g/mol
Synonyms	4-Bromo-3,3,4,4-tetrafluoro-1-butanol; 1-Butanol, 4-bromo-3,3,4,4-tetrafluoro-; 4-Bromo-3,3,4,4-tetrafluorobutanol; 3,3,4,4-Tetrafluoro-4-bromobutan-1-ol; 4-Bromo-3,3,4,4-tetrafluorobutyl alcohol; 234443-21-1; Butan-1-ol, 4-bromo-3,3,4,4-tetrafluoro-
EINECS	Contact for details

Quality Control

Our 4-Bromo-3,3,4,4-tetrafluorobutan-1-ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is sensitive to strong alkalis and fluorides; store separately from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.8 g/mL
Refractive Index (n20D)	~1.38

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.