Description

(S)-Ketorolac Glucuronide is a major, pharmacologically inactive metabolite of the non-steroidal anti-inflammatory drug (NSAID) Ketorolac tromethamine. This compound is of critical importance in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It serves as a vital reference standard for analytical laboratories in pharmaceutical, clinical, and forensic toxicology sectors, enabling accurate quantification and characterization of Ketorolac metabolism in biological samples.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for analytical method development and validation in drug metabolism studies.
• Bioanalytical Research: Essential for quantifying Ketorolac and its metabolites in plasma, serum, and urine during clinical trials and therapeutic drug monitoring.
• Metabolite Identification & Profiling: Used in LC-MS/MS and HPLC studies to map the metabolic pathways of Ketorolac.
• Forensic Toxicology: Acts as a key calibrant for the accurate detection and confirmation of Ketorolac exposure in forensic investigations.
• Quality Control (QC) in Manufacturing: Employed in the QC laboratories of API and finished dosage form manufacturers to ensure product purity and consistency.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., with FDA, EMA) to demonstrate understanding of a drug's metabolic fate.

Basic Information

Product Name	(S)-Ketorolac Glucuronide
CAS No.	233666-90-5
Molecular Formula	C25H27NO11
Molecular Weight	517.48 g/mol
Synonyms	(S)-Ketorolac Glucuronide; Ketorolac Glucuronide; Ketorolac acyl glucuronide; 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, 2-[(2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]hydrazide glucuronide; Toradol metabolite; (S)-Ketorolac β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our (S)-Ketorolac Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for reference materials. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming batch-specific results for identity, purity, and impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.