Description

1,2-Dioleoyl-Sn-Glycero-3-[n-(5-Amino-1-Carboxypentyl)Iminodiacetic Acid Succinyl] (Nickel Salt) is a specialized, functionalized lipid derivative designed for advanced bioconjugation and metal affinity applications. This compound is critical for researchers and developers requiring precise surface modification and targeted binding in complex biological systems. It is primarily utilized in the development of liposomal drug delivery systems, diagnostic assays, and affinity purification matrices within the pharmaceutical and biotechnology sectors.

Application

• Liposome Functionalization: Key component for creating targeted liposomal drug delivery carriers with surface-exposed metal-chelating groups.
• Protein & Antibody Immobilization: Enables site-specific conjugation of His-tagged proteins or antibodies onto lipid membranes or surfaces for biosensor development.
• Affinity Chromatography Media: Used in the synthesis of stationary phases for the purification of recombinant proteins via immobilized metal affinity chromatography (IMAC).
• Diagnostic Nanoparticles: Integral to the surface engineering of nanoparticles used in in-vitro diagnostics and imaging contrast agents.
• Biomimetic Membrane Research: Serves as a functional building block in model membrane studies to investigate cell signaling and membrane-protein interactions.
• Bioseparation & Extraction: Facilitates the selective capture and separation of biomolecules in complex mixtures for analytical or preparative purposes.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-[n-(5-Amino-1-Carboxypentyl)Iminodiacetic Acid Succinyl] (Nickel Salt)
CAS No.	231615-77-3
Molecular Formula	C55H100N3O12Ni
Molecular Weight	~1062.1 g/mol (Contact for details)
Synonyms	DOGS-NTA-Ni; 1,2-Dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] nickel salt; NTA-DOGS Nickel Salt; Nickel-chelating lipid; NTA(Ni)-DOGS; NTA-DOGS(Ni); N-(5-Amino-1-carboxypentyl)iminodiacetic acid succinyl dioleoyl glycerol nickel complex; DODGSNTA-Ni
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-[n-(5-Amino-1-Carboxypentyl)Iminodiacetic Acid Succinyl] (Nickel Salt) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, TLC for identity, and elemental analysis for nickel content, to ensure consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Nickel Content	Contact for details
Solubility	Chloroform, Methanol, DMSO
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.