Description

3-Fluoro-4-(Trifluoromethyl)Cinnamic Acid is a high-value fluorinated cinnamic acid derivative, distinguished by its unique trifluoromethyl and fluorine substituents. This compound is a critical pharmaceutical intermediate and building block for advanced organic synthesis, offering enhanced metabolic stability and lipophilicity to target molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorinated aromatic systems into novel compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting metabolic diseases, inflammation, and central nervous system disorders.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atoms contribute to improved biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal compounds and electron-transport materials in organic light-emitting diodes (OLEDs) due to its electronic properties.
• Chemical Biology Probes: Employed in the design of fluorinated probes and tags for studying biological processes and protein interactions.
• Polymer Modification: Acts as a monomer or cross-linking agent for introducing fluorinated aromatic groups into specialty polymers to alter surface properties and chemical resistance.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Heck reactions, and as a precursor for other fluorinated fine chemicals via functional group transformations.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethyl)Cinnamic Acid
CAS No.	231291-13-7
Molecular Formula	C10H6F4O2
Molecular Weight	234.15 g/mol
Synonyms	(E)-3-(3-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid; 3-Fluoro-4-(trifluoromethyl)cinnamic acid; trans-3-(3-Fluoro-4-(trifluoromethyl)phenyl)-2-propenoic acid; 3-Fluoro-α-(trifluoromethyl)cinnamic acid (ambiguous, verify structure); 2-Propenoic acid, 3-(3-fluoro-4-(trifluoromethyl)phenyl)-, (2E)-; 3-Fluoro-4-trifluoromethylcinnamic acid; (E)-3-[3-Fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Trifluoromethyl)Cinnamic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity intermediates for GLP or cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.