Description

n-Acetyl Retigabine is a key pharmaceutical intermediate and a chemically modified derivative of the active pharmaceutical ingredient retigabine. This compound matters for its critical role in the synthesis and development of advanced neurological therapeutics, offering a pathway for prodrug development and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on neuroscience and anticonvulsant drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of retigabine and its related analogs for neurological research.
• Prodrug Development: Used in the design and evaluation of prodrug candidates to enhance the bioavailability or delivery profile of retigabine.
• Metabolic and Pharmacokinetic Studies: Employed as a reference standard or metabolite in ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Neurological Research: Applied in preclinical research to investigate potassium channel (KCNQ) openers and mechanisms for treating epilepsy and neuropathic pain.
• Chemical Reference Standard: Utilized as a high-purity standard for analytical method development and quality control in API manufacturing.
• Academic & Contract Research: Supports synthetic chemistry and medicinal chemistry programs in academic and commercial research settings.

Basic Information

Product Name	n-Acetyl Retigabine
CAS No.	229970-68-7
Molecular Formula	C18H19FN2O2
Molecular Weight	314.36 g/mol
Synonyms	N-Acetylretigabine; N-Acetyl ezogabine; 2-Acetamido-4-(2-fluorobenzylamino)-1-ethyl-1H-imidazole-5-carboxamide; Retigabine N-acetate; D-23129 N-Acetyl; Acetyl Retigabine; Ethyl N-[2-amino-4-[[(2-fluorophenyl)methyl]amino]phenyl]carbamate acetate
EINECS	Contact for details

Quality Control

Our n-Acetyl Retigabine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.