Description

Alanine, 3-Cyano-n-[(1,1-Dimethylethoxy)Carbonyl]- (9Ci) is a specialized Boc-protected amino acid derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex peptide and peptidomimetic structures, particularly those requiring the introduction of a cyano-functionalized alanine side chain. This high-purity intermediate is essential for research and development in pharmaceutical chemistry, specifically for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide-based drugs and protease inhibitors.
• Peptidomimetic Research: Used to incorporate non-natural amino acid residues with a cyano group into peptide backbones to enhance stability and bioactivity.
• Combinatorial Chemistry: Serves as a valuable building block in solid-phase and solution-phase peptide synthesis libraries for drug discovery screening.
• API Development: Employed in the research-scale and pilot-scale production of complex target molecules for preclinical studies.
• Bioconjugation: The cyano and protected amine functionalities can be utilized for further chemical modifications and linker attachments.
• Academic & Institutional R&D: Used in university and research institute laboratories for studies in synthetic methodology and chemical biology.

Basic Information

Product Name	Alanine, 3-Cyano-n-[(1,1-Dimethylethoxy)Carbonyl]- (9Ci)
CAS No.	229028-67-5
Molecular Formula	C10H16N2O4
Molecular Weight	228.25 g/mol
Synonyms	Boc-3-cyano-L-alanine; N-Boc-3-cyano-L-alanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-cyanopropanoic acid; tert-Butyl (1S)-1-carboxy-2-cyanoethylcarbamate; Boc-Cya-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-cyanopropanoic acid; 3-Cyano-N-[(1,1-dimethylethoxy)carbonyl]alanine; N-(tert-Butoxycarbonyl)-3-cyano-L-alanine
EINECS	Contact for details

Quality Control

Our Alanine, 3-Cyano-n-[(1,1-Dimethylethoxy)Carbonyl]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and specific impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.