Description

1-(2-Hydroxy-4-Trifluoromethyl-Phenyl)-Ethanone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a hydroxyl group and a trifluoromethyl substituent, makes it a versatile precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioactivity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Advanced Material Precursor: Serves as a monomer or intermediate in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development, catalysis studies, and the creation of complex molecular architectures.
• Fluorine Chemistry: An essential substrate for studying fluorination reactions and the effects of fluorine substitution on chemical reactivity and physical properties.

Basic Information

Product Name	1-(2-Hydroxy-4-Trifluoromethyl-Phenyl)-Ethanone
CAS No.	228572-69-8
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	2'-Hydroxy-4'-(trifluoromethyl)acetophenone; 1-(2-Hydroxy-4-(trifluoromethyl)phenyl)ethan-1-one; 2-Acetyl-5-(trifluoromethyl)phenol; 4-Trifluoromethyl-2-hydroxyacetophenone; α-Hydroxy-α,α,α-trifluoro-p-acetophenol; TFMPA derivative
EINECS	Contact for details

Quality Control

Our 1-(2-Hydroxy-4-Trifluoromethyl-Phenyl)-Ethanone is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to consistent quality and traceability supports your R&D and scale-up processes with reliable material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.