Description

(S)-1-Boc-2-Cyanopyrrolidine is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its role in the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in asymmetric synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors and other biologically active molecules.
• Asymmetric Synthesis: Used as a precursor for introducing the (S)-2-cyanopyrrolidine moiety into target compounds.
• Peptidomimetic Research: Serves as a constrained proline analog in the design and development of novel peptide-based therapeutics.
• API Development: Employed in the research and scale-up manufacturing of Active Pharmaceutical Ingredients (APIs).
• Chemical Biology: Utilized as a tool compound for studying enzyme mechanisms and biological pathways.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	(S)-1-Boc-2-Cyanopyrrolidine
CAS No.	228244-04-0
Molecular Formula	C10H16N2O2
Molecular Weight	196.25 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine; (S)-1-Boc-2-cyanopyrrolidine; (S)-2-Cyano-1-(tert-butoxycarbonyl)pyrrolidine; (S)-N-Boc-2-cyanopyrrolidine; tert-Butyl (2S)-2-cyanopyrrolidine-1-carboxylate; (S)-1-Boc-2-pyrrolidinecarbonitrile; (S)-2-Cyano-N-Boc-pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-2-Cyanopyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard purity assays. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.