Description

Ethyl 4-Fluoro-3-oxopentanoate is a versatile fluorinated β-ketoester building block, essential for the synthesis of complex organic molecules. Its value lies in the strategic introduction of fluorine and a reactive ketone functionality, enabling precise molecular modifications that are critical in advanced chemical development. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used to construct fluorinated heterocycles and other complex structures found in modern herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or building block for developing novel fluorinated polymers and specialty materials with unique properties.
• Chemical Biology & Probe Development: Employed in the creation of fluorinated molecular probes and tags for studying biological mechanisms.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed and other metal-mediated coupling reactions to form carbon-carbon bonds.
• Asymmetric Synthesis: Utilized in chiral synthesis pathways to introduce fluorinated chiral centers into target molecules.

Basic Information

Item	Details
Product Name	Ethyl 4-Fluoro-3-oxopentanoate
CAS No.	227184-02-3
Molecular Formula	C7H11FO3
Molecular Weight	162.16 g/mol
Synonyms	4-Fluoro-3-oxopentanoic acid ethyl ester; Ethyl 4-fluoroacetoacetate; 4-Fluoro-3-oxovaleric acid ethyl ester; Ethyl 4-fluoro-3-oxovalerate; 3-Oxo-4-fluoropentanoic acid ethyl ester; 227184-02-3; 4-Fluoroacetylacetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Fluoro-3-oxopentanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.