Description

2-Cyano-n-Boc-Dl-Phenylalanine is a protected amino acid derivative of significant importance in synthetic organic and medicinal chemistry. This compound serves as a versatile and crucial building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of the phenylalanine moiety with orthogonal protecting groups. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules. The Boc (tert-butoxycarbonyl) protecting group offers stability under a wide range of reaction conditions, making this intermediate highly valuable for multi-step synthetic sequences.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid building block to incorporate modified phenylalanine residues.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of inhibitors for enzymes like HIV protease and renin.
• Chemical Biology Research: Employed in the synthesis of labeled peptides, activity-based probes, and other tools for studying protein function and interactions.
• Combinatorial Chemistry: Utilized in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Academic Research: A valuable reagent for methodological studies in asymmetric synthesis and the development of new coupling or deprotection strategies.

Basic Information

Product Name	2-Cyano-n-Boc-Dl-Phenylalanine
CAS No.	226924-21-6
Molecular Formula	C₁₅H₁₈N₂O₄
Molecular Weight	290.32 g/mol
Synonyms	N-Boc-2-cyano-DL-phenylalanine; (RS)-2-Cyano-3-phenyl-N-[(tert-butoxy)carbonyl]propionamide; Boc-DL-2-Cyano-Phe-OH; tert-Butyl (1-cyano-2-phenylethyl)carbamate; DL-2-Cyano-N-Boc-phenylalanine; 2-Cyano-3-phenylpropanoic acid N-Boc derivative; (DL)-N-(tert-Butoxycarbonyl)-2-cyano-3-phenylalanine
EINECS	Contact for details

Quality Control

Our 2-Cyano-n-Boc-Dl-Phenylalanine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, chiral purity (where applicable), and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all relevant specifications is available for every batch upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.