Description

Benzenemethanamine, α-Ethynyl-3-Fluoro- (9Ci) is a specialized fluorinated aromatic amine building block featuring an ethynyl substituent. This compound is valued for its unique molecular architecture, which combines a reactive amine group with a fluorinated benzene ring and an alkyne handle, enabling diverse synthetic modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing complex molecules, including potential active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental stability.
• Material Science Research: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers, resins, and advanced organic frameworks (e.g., MOFs, COFs).
• Chemical Biology Probes: Employed in the creation of fluorescent tags, affinity labels, and other molecular probes due to the reactivity of the alkyne group in click chemistry reactions.
• Ligand and Catalyst Development: Provides a scaffold for designing novel ligands for asymmetric catalysis and metal-organic complexes.

Basic Information

Product Name	Benzenemethanamine, α-Ethynyl-3-Fluoro- (9Ci)
CAS No.	226698-97-1
Molecular Formula	C9H8FN
Molecular Weight	149.17 g/mol
Synonyms	α-Ethynyl-3-fluorobenzylamine; 1-(3-Fluorophenyl)-2-propyn-1-amine; 3-Fluoro-α-ethynylbenzenemethanamine; (3-Fluorophenyl)(prop-2-yn-1-yl)amine; 3-Fluoro-α-ethynylbenzylamine; Benzenemethanamine, α-ethynyl-3-fluoro-; (3-Fluorobenzyl)ethynylamine
EINECS	Contact for details

Quality Control

Our production of Benzenemethanamine, α-Ethynyl-3-Fluoro- (9Ci) adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your R&D and scale-up activities under quality-by-design (QbD) principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Typical: 97-99%)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.