Description

2-(4-Fluorophenyl)-5,5-Dimethyl-1,3,2-Dioxaborinane is a high-purity, cyclic boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its role as a stable, protected boronic acid equivalent for Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, process development, and specialty chemical production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) containing fluorinated biaryl motifs, leveraging the stability of the dioxaborinane ring.
• Agrochemical Synthesis: Used to construct fluorinated aromatic cores in the development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as polymers for OLEDs or OFETs, where fluorine substitution tunes electronic properties.
• Suzuki-Miyaura Cross-Coupling: Acts as a stable, air- and moisture-tolerant boronate reagent for palladium-catalyzed carbon-carbon bond formation, often preferred over boronic acids for challenging substrates.
• Chemical Biology & Probe Development: Utilized in the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of fluorinated fine chemicals.

Basic Information

Product Name	2-(4-Fluorophenyl)-5,5-Dimethyl-1,3,2-Dioxaborinane
CAS No.	225916-39-2
Molecular Formula	C12H16BFO2
Molecular Weight	222.07 g/mol
Synonyms	5,5-Dimethyl-2-(4-fluorophenyl)-1,3,2-dioxaborinane; 4-Fluorophenyl-5,5-dimethyl-1,3,2-dioxaborinane; (4-Fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 2-(4-Fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 4-Fluorophenylboronic acid 2,2-dimethyltrimethylene ester; 4-Fluorophenylboronic acid neopentyl glycol ester; 2-(p-Fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 2-(4-Fluorophenyl)-5,5-Dimethyl-1,3,2-Dioxaborinane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC analysis, to confirm identity, assay, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.