Description

2,5-Dioxopyrrolidin-1-Yl n-{n-[(2-Isopropyl-1,3-Thiazol-4-Yl)Methyl]-n-Methylcarbamoyl}-L-Valinate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for enabling precise amide bond formation in peptide and protein conjugation strategies, offering superior reactivity and selectivity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, including targeted drug delivery systems and bioconjugates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex small-molecule APIs and peptide-based drugs.
• Bioconjugation Reagent: Used for the site-specific labeling and modification of proteins, antibodies, and other biomolecules for therapeutic and diagnostic applications.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling (ABPP) and target identification studies.
• Linker Chemistry: Serves as a versatile linker in the construction of antibody-drug conjugates (ADCs) and other targeted therapies.
• Chemical Biology Tool: Facilitates the study of protein function and interaction through controlled covalent modification.
• Process Development: Used in scale-up and optimization of synthetic routes for GMP manufacturing of clinical trial materials.

Basic Information

Product Name	2,5-Dioxopyrrolidin-1-Yl n-{n-[(2-Isopropyl-1,3-Thiazol-4-Yl)Methyl]-n-Methylcarbamoyl}-L-Valinate
CAS No.	224631-15-6
Molecular Formula	C19H28N4O5S
Molecular Weight	424.51 g/mol
Synonyms	N-[(2-Isopropyl-1,3-thiazol-4-yl)methyl]-N-methyl-L-valyloxysuccinimide; L-Valine, N-[[(2-isopropyl-4-thiazolyl)methyl]methylcarbamoyl]-, 2,5-dioxo-1-pyrrolidinyl ester; N-{N-[(2-Isopropyl-1,3-thiazol-4-yl)methyl]-N-methylcarbamoyl}-L-valine N-hydroxysuccinimide ester; Valine-NHS ester derivative; Thiazole-Val-OSu; ADC Linker Intermediate; Succinimidyl ester of N-[(2-isopropylthiazol-4-yl)methyl]-N-methyl-L-valine
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. Our quality system is designed to meet the stringent requirements of GMP (Good Manufacturing Practice) guidelines for advanced intermediates. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity and purity. Certificates of Analysis (COA) with detailed chromatographic data are provided with each batch to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.