Description

2-(Di-tert-Butylphosphino)Biphenyl is a specialized, air-sensitive organophosphorus ligand widely used in transition metal catalysis. This compound matters for its exceptional electron-donating properties and steric bulk, which are critical for enabling challenging cross-coupling and hydrogenation reactions. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for developing efficient synthetic routes.

Application

• Catalytic Cross-Coupling Reactions: A key ligand for Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings in pharmaceutical intermediate synthesis.
• Asymmetric Hydrogenation: Used in the preparation of chiral catalysts for the enantioselective reduction of olefins and ketones.
• Polymerization Catalysis: Serves as a co-catalyst in olefin polymerization and copolymerization processes for specialty polymers.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic transformations in fine chemical synthesis.
• Agrochemical Synthesis: Employed in the catalytic production of complex, high-value active ingredients.
• Material Science: Facilitates the synthesis of organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-(Di-tert-Butylphosphino)Biphenyl
CAS No.	224311-51-7
Molecular Formula	C20H27P
Molecular Weight	298.40 g/mol
Synonyms	2-(Di-tert-butylphosphino)biphenyl; Di-tert-butyl(2-biphenylyl)phosphine; DTBPB; 2-Biphenylyldi-tert-butylphosphine; (2-Biphenylyl)di-tert-butylphosphine; JohnPhos (Note: JohnPhos typically refers to a related ligand; this is a common search alias); tBuDavePhos; DavePhos (common trade/abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 2-(Di-tert-Butylphosphino)Biphenyl is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure consistency and performance for catalytic applications. A Certificate of Analysis (COA) detailing purity, identity, and moisture content is supplied with each shipment. Our quality systems support compliance with cGMP and ISO standards for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material must be stored under an inert atmosphere (argon or nitrogen). Recommended storage temperature is 2-8°C in a cool, dry, and well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.