Description

4-(Piperidin-4-Yloxy)Benzonitrile is a high-purity, versatile chemical intermediate featuring a benzonitrile core linked to a piperidine moiety via an ether bridge. This molecular architecture makes it a critical building block for the synthesis of complex, biologically active molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel compounds targeting various therapeutic areas and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Serves as a precursor in the design and production of advanced herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Used in organometallic chemistry to create novel ligands for catalytic systems and material science applications.
• Chemical Biology Probe Synthesis: Employed in the construction of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	4-(Piperidin-4-Yloxy)Benzonitrile
CAS No.	224178-67-0
Molecular Formula	C12H14N2O
Molecular Weight	202.25 g/mol
Synonyms	4-(4-Piperidyloxy)benzonitrile; 4-(Piperidin-4-yloxy)benzonitrile; 4-Cyano-1-(4-piperidinyloxy)benzene; Benzonitrile, 4-(4-piperidinyloxy)-; 1-(4-Cyanophenoxy)-4-piperidine; 4-(1-Piperidinyloxy)benzonitrile (common misnomer); 4-Piperidinol, 1-(4-cyanophenyl) ether
EINECS	Contact for details

Quality Control

Our production of 4-(Piperidin-4-Yloxy)Benzonitrile adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, and our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.