Description

5-(-)-Menthyloxycarbonyltetrahydrofolate is a high-purity, advanced folate derivative used as a critical chiral intermediate in pharmaceutical synthesis. This compound matters for its role in the production of enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical control is paramount for efficacy and safety. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries developing novel therapeutics, particularly in oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel folate-targeted chemotherapeutic agents and enzyme inhibitors.
• Biochemical Research: Used in enzymatic studies and as a precursor for labeled compounds in metabolic pathway tracing and drug metabolism research.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective synthesis for complex molecule construction.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Precursor for Conjugates: Used in the development of folate-drug conjugates for targeted drug delivery systems.

Basic Information

Product Name	5-(-)-Menthyloxycarbonyltetrahydrofolate
CAS No.	224046-81-5
Molecular Formula	C₃₀H₄₁N₇O₇
Molecular Weight	611.69 g/mol
Synonyms	(-)-Menthyl 5,6,7,8-tetrahydrofolate; L-Menthyl tetrahydrofolate; 5-(-)-Menthyl THF; 5-Menthyloxycarbonyl-5,6,7,8-tetrahydrofolic acid; (6S)-5,6,7,8-Tetrahydrofolic acid (-)-menthyl ester; Tetrahydrofolic acid menthyl ester; Folinic acid menthyl ester derivative
EINECS	Contact for details

Quality Control

Our 5-(-)-Menthyloxycarbonyltetrahydrofolate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC and structural confirmation by NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to reach room temperature before opening to minimize condensation and exposure.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.