Description

2-[(1S,2S)-2-Fluorocyclopentyl]-Isoindole-1,3-Dione is a high-purity, stereochemically defined fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals, where the introduction of a fluorine atom and specific stereochemistry can dramatically alter biological activity and metabolic stability. Pharmaceutical researchers and process chemists need this material for the synthesis of potential drug candidates, particularly in therapeutic areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated active ingredients for crop protection products, where fluorine incorporation enhances efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialized fluorinated polymers or small molecules with unique electronic or surface properties.
• Chemical Biology Probes: Utilized as a building block for creating fluorinated probes and tags to study biological mechanisms and protein interactions.
• Process Chemistry & Scale-Up: Provides a defined starting point for optimizing synthetic routes and scaling the production of complex molecules from laboratory to pilot plant scale.

Basic Information

Product Name	2-[(1S,2S)-2-Fluorocyclopentyl]-Isoindole-1,3-Dione
CAS No.	223761-83-9
Molecular Formula	C₁₃H₁₂FNO₂
Molecular Weight	233.24 g/mol
Synonyms	(1S,2S)-2-(1,3-Dioxoisoindolin-2-yl)cyclopentyl fluoride; (1S,2S)-2-Fluoro-N-(phthalimido)cyclopentane; 2-[(1S,2S)-2-Fluorocyclopentyl]phthalimide; 2-[(1S,2S)-2-Fluorocyclopentyl]isoindoline-1,3-dione; (1S,2S)-2-Fluorocyclopentyl phthalimide; N-[(1S,2S)-2-Fluorocyclopentyl]phthalimide; Fluorinated cyclopentyl phthalimide; Chiral fluorocyclopentyl phthalimide derivative
EINECS	Contact for details

Quality Control

Our 2-[(1S,2S)-2-Fluorocyclopentyl]-Isoindole-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.