Description

(As,As)-1,1'-Bis[4-(Dimethylamino)Benzyl]-(R,R)-2,2'-Bis(Diphenylphosphino)-1,1'-binaphthyl is a sophisticated, chiral bisphosphine ligand with a unique binaphthyl backbone and arsine functionalities. This compound matters for its exceptional ability to induce stereoselectivity in transition metal-catalyzed reactions, enabling the production of high-value enantiomerically pure intermediates. It is primarily needed by research chemists and process development scientists in the pharmaceutical and fine chemical industries for asymmetric synthesis, including hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Asymmetric Cross-Coupling: Facilitates stereocontrolled C-C and C-X bond-forming reactions critical for constructing complex molecular architectures.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer active pharmaceutical ingredients (APIs) and advanced chiral synthons.
• Catalyst Development & Screening: Used in academic and industrial R&D to develop new catalytic systems for challenging transformations.
• Fine Chemical Manufacturing: Applied in the synthesis of specialty chemicals, flavors, fragrances, and agrochemicals requiring high optical purity.
• Material Science Research: Potential utility in creating chiral surfaces or polymers with specific stereochemical properties.

Basic Information

Product Name	(As,As)-1,1'-Bis[4-(Dimethylamino)Benzyl]-(R,R)-2,2'-Bis(Diphenylphosphino)-1,1'-binaphthyl
CAS No.	223725-09-5
Molecular Formula	C72H68As2N2P2
Molecular Weight	1181.06 g/mol
Synonyms	(R,R)-As-BINAP-A; (R,R)-As-BINAP-A Derivative; (R,R)-1,1'-Binaphthyl-2,2'-diyl)bis(diphenylphosphine) Arsine Analog; (R,R)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl Arsine Derivative; (As,As)-BINAP Derivative; Chiral Bis(arsino)bis(phosphine) Ligand; (R)-As-BINAP-A; (R,R)-DACH-aryl As-BINAP-A
EINECS	Contact for details

Quality Control

Every batch of this high-value chiral ligand is produced and controlled under strict inert atmosphere conditions to prevent oxidation. Our rigorous quality testing includes advanced chiral analytical techniques to ensure stereochemical integrity and high purity, meeting the exacting standards for catalysis research. A comprehensive Certificate of Analysis (COA) detailing chiral purity, assay, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container under an inert atmosphere (argon or nitrogen), protected from light. Store at 2-8°C for long-term stability. This compound is easily oxidized and moisture-sensitive; handle and package using standard Schlenk-line or glovebox techniques to maintain purity.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.