Description

2-Methyl-D3-n-(4-Nitro-3-Trifluoromethylphenyl)-2-Trimethylsilyloxy-Propamide-3,3,3-D3 is a high-purity, deuterated and silylated advanced pharmaceutical intermediate (API) designed for sophisticated synthesis. This compound is critical for research and development in medicinal chemistry, particularly for creating isotopically labeled drug candidates and metabolites for pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) requiring precise molecular tools.

Application

• Isotope-Labeled Drug Synthesis: Serves as a key building block for the preparation of deuterium-labeled pharmaceutical compounds, enhancing metabolic stability and enabling drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolite Standard Production: Used in the synthesis of stable isotope-labeled internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) bioanalytical assays.
• Medicinal Chemistry Research: Acts as a specialized intermediate in structure-activity relationship (SAR) studies and the development of novel therapeutic agents targeting specific biological pathways.
• Proteomics & Biomarker Discovery: Employed in chemical proteomics for activity-based protein profiling (ABPP) and the development of chemical probes.
• Process Chemistry Development: Used in route scouting and optimization for the scalable synthesis of complex target molecules in pharmaceutical manufacturing.

Basic Information

Item	Detail
Product Name	2-Methyl-D3-n-(4-Nitro-3-Trifluoromethylphenyl)-2-Trimethylsilyloxy-Propamide-3,3,3-D3
CAS No.	223134-75-6
Molecular Formula	C14H13D6F3N2O4Si
Molecular Weight	382.42 g/mol
Synonyms	2-Methyl-2-(trimethylsilyloxy)-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide-3,3,3-d3; 2-Trimethylsilyloxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide-d3; Deuterated TMS-protected nitro-CF3 anilide; Propamide-3,3,3-d3, 2-methyl-2-[(trimethylsilyl)oxy]-N-[4-nitro-3-(trifluoromethyl)phenyl]-; Advanced deuterated silyl ether intermediate; API Intermediate 223134-75-6
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-D3-n-(4-Nitro-3-Trifluoromethylphenyl)-2-Trimethylsilyloxy-Propamide-3,3,3-D3 is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including NMR (1H, 13C, 19F), HPLC, and LC-MS, to ensure high chemical and isotopic purity and compliance with client specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.