Description

Lopinavir Metabolite m-3/m-4 CAS NO 221553-72-6 is a key intermediate and reference standard in the synthesis and analytical profiling of the antiretroviral drug Lopinavir. This compound is critical for pharmaceutical research and development, enabling the study of drug metabolism, pharmacokinetics, and the development of robust quality control methods. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories focused on antiviral drug development and regulatory compliance.

Application

• Pharmaceutical Reference Standard for the quantification and identification of Lopinavir metabolites in biological matrices during pharmacokinetic studies.
• Metabolite Profiling in drug development to understand the metabolic pathways and clearance mechanisms of Lopinavir.
• Analytical Method Development and Validation for HPLC, LC-MS, and other chromatographic assays used in quality control laboratories.
• Impurity Characterization to identify and control process-related impurities in active pharmaceutical ingredient (API) manufacturing.
• Bioanalytical Research supporting clinical trials and regulatory submissions for HIV/AIDS treatments.
• Synthetic Intermediate for the chemical synthesis of related compounds and derivatives in medicinal chemistry research.

Basic Information

Product Name	Lopinavir Metabolite m-3/m-4
CAS No.	221553-72-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Lopinavir Metabolite M3; Lopinavir Metabolite M4; Lopinavir Related Compound; (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide; ABT-378 Metabolite
EINECS	Contact for details

Quality Control

Our Lopinavir Metabolite m-3/m-4 is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by high-performance liquid chromatography (HPLC). We provide full traceability and Certificates of Analysis (COA) are available upon request to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity: ≤ 1.0% Total impurities: ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.